The bone cell microenvironment consists of bone forming osteoblasts, bone resorbing osteoclasts and thei precursors, as well as immune and vascular cells. Complex endocrine and local signals are integrated to mediate bone cell development and function. This group's research focuses on understanding select aspects of the cell and molecular interactions that are required for normal bone development as well as those that may contribute to age-associated and inflammatory-mediated pathological bone loss.

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Panel on top shows scanning electron micrograph of isolated osteoclast resorbing bone. Panel on bottom is a cartoon depicting cytokine and cell interactions that may contribute to recruitment, differentiation, and activation of bone resorbing osteoclasts (depicted in red).